Giuseppe Avella

ClickGene Research

PhD student in Comparison of the efficacy of novel, lipid-based reagents for artificial nuclease delivery through targeting of GFP at NICB, Dublin City University (DCU). The aim of the project is to establish the most potent combinations of artificial nuclease/DNA probes and lipid-based transfection reagents improving the efficiency of delivery and gene targeting, minimizing the effects on cell viability.

Supervisor

Niall Barron

Thesis

Comparison of the efficacy of novel, lipid-based reagents for artificial nuclease delivery through targeting of GFP

Scientific Background

  • Research Trainee at Karolinska Institute, Isolation and evaluation of human hepatic cells and amniotic epithelial stem cells to correct liver diseases, with the purpose of identifying hepatocyte and pluripotent stem cells suitable for cell transplantation. Supervisors: Prof. Stephen Strom and Prof. Roberto Gramignoli.
  • Master’s Degree in Molecular, health and nutritional biology at University of Urbino “Carlo Bo”. Master’s Thesis in Physical Chemistry, Characterization of carcinogenic zeolite fibers and interactions with models of membrane under the supervision of Prof. Maria Francesca Ottaviani.
  • Internship at University of Lisbon, Development of Metal-Organic Frameworks and Nanoporous materials for delivery of small molecules, Supervisors: Prof. Fernando Antunes and Prof. Joao Silva.
  • Bachelor’s Thesis on Histochemical and immunohistochemical study of gastric neuroendocrine hyperplasia, Supervisor: Prof. D’Armiento Francesco Paolo.